FHIT anticorps

N° du produit ABIN4909573

Détail du produit anti-FHIT anticorps

Antigène: FHIT (Fragile Histidine Triad (FHIT))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FHIT est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Réactivité croisée: Humain

Purification: Purified by Protein G.

Immunogène: This FHIT antibody is generated from a mouse immunized with a recombinant protein.

Clone: 3C2

Isotype: IgG1

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur FHIT

Antigène: FHIT (Fragile Histidine Triad (FHIT))

Autre désignation: FHIT (FHIT Produits)

Synonymes: anticorps AP3Aase, anticorps FRA3B, anticorps FHIT, anticorps zgc:73176, anticorps AW045638, anticorps Fra14A2, anticorps LOC100223655, anticorps fragile histidine triad, anticorps fragile histidine triad gene, anticorps fragile histidine triad protein, anticorps fragile histidine triad L homeolog, anticorps FHIT, anticorps Fhit, anticorps fhit, anticorps PY07476, anticorps fhit.L

Sujet:

Synonyms: FRA3B, AP3Aase, Bis(5'-adenosyl)-triphosphatase, AP3A hydrolase, Diadenosine 5',5'''-P1,P3-triphosphate hydrolase, Dinucleosidetriphosphatase, Fragile histidine triad protein, FHIT

Background: Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.

ID gène: 2272

UniProt: P49789