SLC26A6 anticorps (AA 431-500)

N° du produit ABIN4914082

Détail du produit anti-SLC26A6 anticorps

Antigène: SLC26A6 (Solute Carrier Family 26, Member 6 (SLC26A6))

Épitope: AA 431-500

Reactivité: Porc, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC26A6 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Réactivité croisée: Porc, Rat

Homologie: Mouse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SLC26A6

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur SLC26A6

Antigène: SLC26A6 (Solute Carrier Family 26, Member 6 (SLC26A6))

Autre désignation: SLC26A6 (SLC26A6 Produits)

Synonymes: anticorps B930010B04Rik, anticorps CFEX, anticorps Pat1, anticorps MGC81960, anticorps SLC26A6, anticorps slc26a6, anticorps MGC145603, anticorps si:dkey-20d21.8, anticorps solute carrier family 26 member 6, anticorps solute carrier family 26, member 6, anticorps solute carrier family 26 member 6 S homeolog, anticorps anion exchanger SLC26A6, anticorps SLC26A6, anticorps Slc26a6, anticorps slc26a6.S, anticorps slc26a6

Sujet:

Synonyms: Solute carrier family 26 member 6, Anion exchange transporter, Pendrin-like protein 1, Pendrin-L1, SLC26A6

Background: Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney.

ID gène: 65010

UniProt: Q9BXS9

Pathways: Dicarboxylic Acid Transport