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SLC26A6 anticorps (AA 431-500) (Biotin)

SLC26A6 Reactivité: Porc, Rat WB, ELISA, IHC (p), IHC (fro) Hôte: Lapin Polyclonal Biotin
N° du produit ABIN4914093
  • Antigène Voir toutes SLC26A6 Anticorps
    SLC26A6 (Solute Carrier Family 26, Member 6 (SLC26A6))
    Épitope
    • 14
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 431-500
    Reactivité
    • 21
    • 14
    • 14
    • 2
    • 1
    Porc, Rat
    Hôte
    • 31
    • 3
    • 2
    Lapin
    Clonalité
    • 36
    Polyclonal
    Conjugué
    • 13
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SLC26A6 est conjugé à/à la Biotin
    Application
    • 25
    • 13
    • 13
    • 9
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Porc, Rat
    Homologie
    Mouse
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human SLC26A6
    Isotype
    IgG
    Top Product
    Discover our top product SLC26A6 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C for 12 months.
    Date de péremption
    12 months
  • Antigène
    SLC26A6 (Solute Carrier Family 26, Member 6 (SLC26A6))
    Autre désignation
    SLC26A6 (SLC26A6 Produits)
    Synonymes
    anticorps B930010B04Rik, anticorps CFEX, anticorps Pat1, anticorps MGC81960, anticorps SLC26A6, anticorps slc26a6, anticorps MGC145603, anticorps si:dkey-20d21.8, anticorps solute carrier family 26 member 6, anticorps solute carrier family 26, member 6, anticorps solute carrier family 26 member 6 S homeolog, anticorps anion exchanger SLC26A6, anticorps SLC26A6, anticorps Slc26a6, anticorps slc26a6.S, anticorps slc26a6
    Sujet

    Synonyms: Solute carrier family 26 member 6, Anion exchange transporter, Pendrin-like protein 1, Pendrin-L1, SLC26A6

    Background: Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney.

    ID gène
    65010
    UniProt
    Q9BXS9
    Pathways
    Dicarboxylic Acid Transport
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