ITCH anticorps
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- Antigène Voir toutes ITCH Anticorps
- ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ITCH est non-conjugé
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Application
- Western Blotting (WB)
- Purification
- Antigen affinity
- Immunogène
- Amino acids AMQQFNQRFIYGNQDLFATSQSKEFDPL of human ITCH were used as the immunogen for the ITCH antibody.
- Isotype
- IgG
- Top Product
- Discover our top product ITCH Anticorps primaire
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- Indications d'application
- Optimal dilution of the ITCH antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL
- Restrictions
- For Research Use only
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- Buffer
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
- Stock
- -20 °C
- Stockage commentaire
- After reconstitution, the ITCH antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- Antigène
- ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))
- Autre désignation
- ITCH / AIF4 (ITCH Produits)
- Synonymes
- anticorps AIF4, anticorps AIP4, anticorps NAPP1, anticorps dJ468O1.1, anticorps 6720481N21Rik, anticorps 8030492O04Rik, anticorps A130065M08, anticorps C230047C07Rik, anticorps itchy E3 ubiquitin protein ligase, anticorps itchy, E3 ubiquitin protein ligase, anticorps ITCH, anticorps Itch
- Sujet
- ITCH is an ubiquitin-conjugating enzyme. This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
- UniProt
- Q96J02
- Pathways
- Activation of Innate immune Response, CXCR4-mediated Signaling Events
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