KEAP1 anticorps (AA 422-449)
-
- Antigène Voir toutes KEAP1 Anticorps
- KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
-
Épitope
- AA 422-449
-
Reactivité
- Humain
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp KEAP1 est non-conjugé
-
Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Réactivité croisée (Details)
- Expected species reactivity: Pig
- Purification
- Antigen affinity purified
- Immunogène
- A portion of amino acids 422-449 from the human protein was used as the immunogen for this KEAP1 antibody.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product KEAP1 Anticorps primaire
-
-
- Indications d'application
- The stated application concentrations are suggested starting amounts. Titration of the KEAP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at 4°C for up to one month. For long term, aliquot the KEAP1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
-
- Antigène
- KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
- Autre désignation
- KEAP1 (KEAP1 Produits)
- Synonymes
- anticorps INrf2, anticorps KLHL19, anticorps INRF2, anticorps mKIAA0132, anticorps Inrf2, anticorps fb36f11, anticorps keap1, anticorps wu:fb36f11, anticorps KEAP1, anticorps klhl19, anticorps zgc:171654, anticorps kelch like ECH associated protein 1, anticorps kelch-like ECH-associated protein 1, anticorps Kelch-like ECH-associated protein 1, anticorps kelch-like ECH-associated protein 1a, anticorps kelch like ECH associated protein 1 L homeolog, anticorps kelch-like ECH-associated protein 1b, anticorps KEAP1, anticorps Keap1, anticorps keap1a, anticorps keap1, anticorps keap1.L, anticorps keap1b
- Sujet
- KEAP1 acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome [UniProt]
- UniProt
- Q14145
- Pathways
- Maintenance of Protein Location
-