ABCG2
Reactivité: Humain, Souris, Rat
WB
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Titration of the ABCG2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50,Flow Cytometry: 1:10-1:50,IHC (Paraffin): 1:50-1:100
Restrictions
For Research Use only
Format
Liquid
Buffer
In 1X PBS, pH 7.4, with 0.09 % sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C
Stockage commentaire
Aliquot the ABCG2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Antigène
ABCG2
(ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2))
anticorps bcrp, anticorps ABCG2, anticorps ABC15, anticorps ABCP, anticorps BCRP, anticorps BCRP1, anticorps BMDP, anticorps CD338, anticorps CDw338, anticorps EST157481, anticorps GOUT1, anticorps MRX, anticorps MXR, anticorps MXR1, anticorps UAQTL1, anticorps AI428558, anticorps Bcrp1, anticorps ABCG3, anticorps ATP binding cassette subfamily G member 2, anticorps ATP binding cassette subfamily G member 2 (Junior blood group), anticorps ATP binding cassette subfamily G member 2 (Junior blood group) L homeolog, anticorps ATP-binding cassette, sub-family G (WHITE), member 2, anticorps ATP-binding cassette sub-family G member 2, anticorps ABCG2, anticorps abcg2, anticorps abcg2.L, anticorps Abcg2, anticorps LOC100008640
Sujet
ABCG2 is a membrane-associated protein included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.