ATF3 anticorps (AA 140-168)

N° du produit ABIN3029847

Détail du produit anti-ATF3 anticorps

Antigène: ATF3 (Activating Transcription Factor 3 (ATF3))

Épitope: AA 140-168

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATF3 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Réactivité croisée (Details): Expected species reactivity: Mouse, Rat, Bovine

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 140-168 from the human protein was used as the immunogen for this ATF3 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the ATF3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the ATF3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur ATF3

Antigène: ATF3 (Activating Transcription Factor 3 (ATF3))

Autre désignation: ATF3 (ATF3 Produits)

Synonymes: anticorps zgc:55526, anticorps ATF3, anticorps LRG-21, anticorps LRF-1, anticorps LRFI, anticorps atf-3, anticorps activating transcription factor 3, anticorps activating transcription factor 3 L homeolog, anticorps atf3, anticorps ATF3, anticorps Atf3, anticorps atf3.L

Sujet: Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.

UniProt: P18847

Pathways: Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Unfolded Protein Response