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Aurora A anticorps (AA 364-392)

AURKA Reactivité: Humain WB, ELISA, IF, FACS Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3030073
  • Antigène Voir toutes Aurora A (AURKA) Anticorps
    Aurora A (AURKA) (Aurora Kinase A (AURKA))
    Épitope
    • 22
    • 11
    • 9
    • 8
    • 8
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 364-392
    Reactivité
    • 112
    • 67
    • 38
    • 21
    • 18
    • 12
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    Humain
    Hôte
    • 106
    • 18
    • 1
    Lapin
    Clonalité
    • 99
    • 25
    Polyclonal
    Conjugué
    • 76
    • 8
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Aurora A est non-conjugé
    Application
    • 90
    • 47
    • 32
    • 24
    • 15
    • 11
    • 10
    • 7
    • 6
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)
    Purification
    Purified
    Immunogène
    A portion of amino acids 364-392 from the human protein was used as the immunogen for this Aurora-A antibody.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product AURKA Anticorps primaire
  • Indications d'application
    Titration of the Aurora-A antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50,Flow Cytometry: 1:10-1:50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Aliquot the Aurora-A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Antigène
    Aurora A (AURKA) (Aurora Kinase A (AURKA))
    Autre désignation
    Aurora-A (AURKA Produits)
    Sujet
    Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Auroria kinase A may play a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. It may be involved in microtubule formation and/or stabilization. This protein has also been postulated to play a key role during tumor development and progression. Aurora kinase A localizes on centrosomes in interphase cells and at each spindle pole in mitosis. It is highly expressed in testis, weakly in skeletal muscle, thymus and spleen, and also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines. Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, and decreases rapidly afterward. Defects in Aurora kinase A are responsible for numerical centrosome aberrations including aneuploidy.
    UniProt
    O14965
    Pathways
    Cycle Cellulaire, Asymmetric Protein Localization
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