AXIN2 anticorps (AA 816-843)

N° du produit ABIN3030089

Détail du produit anti-AXIN2 anticorps

Antigène: AXIN2 (Axin 2 (AXIN2))

Épitope: AA 816-843

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AXIN2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Réactivité croisée (Details): Expected species reactivity: Mouse, Rat

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 816-843 from the human protein was used as the immunogen for this AXIN2 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the AXIN2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the AXIN2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur AXIN2

Antigène: AXIN2 (Axin 2 (AXIN2))

Autre désignation: AXIN2 (AXIN2 Produits)

Synonymes: anticorps AXIL, anticorps ODCRCS, anticorps axil, anticorps wu:fb37c08, anticorps zgc:111942, anticorps axin-2, anticorps xarp, anticorps MGC81576, anticorps arp-A, anticorps axin2, anticorps Axi1, anticorps Axil, anticorps Conductin, anticorps axin 2, anticorps axin 2 (conductin, axil), anticorps axin 2 (conductin, axil) S homeolog, anticorps AXIN2, anticorps axin2, anticorps axin2.S, anticorps Axin2

Sujet: The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

UniProt: Q9Y2T1

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling