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Cyclin D1 anticorps (AA 68-97)

Name: Cyclin D1 anticorps (AA 68-97)
SKU: ABIN3030588
Price: 628.5 EUR
Availability: InStock

CCND1 Reactivité: Humain, Souris WB, ELISA, IHC, IF Hôte: Lapin Polyclonal unconjugated

Western blot analysis of Cyclin D1 antibody and mouse lung lysate. (Cyclin D1 anticorps (AA 68-97))

IHC analysis of FFPE human breast carcinoma tissue stained with Cyclin D1 antibody (Cyclin D1 anticorps (AA 68-97))

IHC

IHC analysis of FFPE human testis tissue stained with Cyclin D1 antibody (Cyclin D1 anticorps (AA 68-97))

IHC

Confocal immunofluorescent analysis of Cyclin D1 antibody with HeLa cells followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (Cyclin D1 anticorps (AA 68-97))

IHC

7 images

N° du produit ABIN3030588

Fiche de données

Antigène Voir toutes Cyclin D1 (CCND1) Anticorps

Cyclin D1 (CCND1)
Épitope
22

21

16

16

12

11

9

9

8

7

7

7

6

6

5

5

3

3

3

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 68-97
Reactivité
235

125

121

40

20

18

16

12

10

9

3

3

3

3

3

2

2

1

1

1

1

1

1
Humain, Souris
Hôte
202

55

1
Lapin
Anticorps secondaires appropriés
Clonalité
192

64
Polyclonal
Conjugué
118

25

20

9

7

5

5

5

5

5

5

4

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1
Cet anticorp Cyclin D1 est non-conjugé
Application
195

86

64

62

40

30

28

27

23

20

19

12

6

5

3

2

2

2

1

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée (Details)

Expected species reactivity: Bovine

Purification

Antigen affinity purified

Immunogène

A portion of amino acids 68-97 from the human protein was used as the immunogen for this Cyclin D1 antibody.

Isotype

Ig Fraction

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Indications d'application

Titration of the Cyclin D1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50

Restrictions

For Research Use only
Format

Liquid

Buffer

In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur

Sodium azide

Précaution d'utilisation

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock

-20 °C

Stockage commentaire

Aliquot the Cyclin D1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Antigène

Cyclin D1 (CCND1)

Abstract

CCND1 Produits

Synonymes

anticorps BCL1, anticorps D11S287E, anticorps PRAD1, anticorps U21B31, anticorps AI327039, anticorps CycD1, anticorps Cyl-1, anticorps bcl-1, anticorps cD1, anticorps cb161, anticorps cycd1, anticorps etID37810.7, anticorps fb52e01, anticorps fc45c08, anticorps fc83a12, anticorps id:ibd1198, anticorps wu:fb52e01, anticorps wu:fc45c08, anticorps wu:fc83a12, anticorps ccnd1b, anticorps prad1, anticorps ccnd1, anticorps ccnd1a, anticorps bcl1, anticorps d11s287e, anticorps u21b31, anticorps CCND1, anticorps cyclin D1, anticorps cyclin D1 S homeolog, anticorps cyclin D1 L homeolog, anticorps CCND1, anticorps Ccnd1, anticorps ccnd1, anticorps ccnd1.S, anticorps ccnd1.L

Sujet

CCND1 is the regulatory component of the Cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. CyclinD-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. [UniProt]

UniProt

P24385

Pathways

Signalisation PI3K-Akt, Cycle Cellulaire, Mitotic G1-G1/S Phases, ER-Nucleus Signaling