EED anticorps (N-Term)

N° du produit ABIN3030800

Détail du produit anti-EED anticorps

Antigène: EED (Embryonic Ectoderm Development (EED))

Épitope: N-Term

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EED est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée (Details): Expected species reactivity: Human, Bovine, Chicken

Purification: Antigen affinity purified

Immunogène: This Eed antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 40-74 amino acids from the N-terminal region of mouse Eed.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the Eed antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Eed antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur EED

Antigène: EED (Embryonic Ectoderm Development (EED))

Autre désignation: Eed (EED Produits)

Synonymes: anticorps Xeed, anticorps heed, anticorps wait1, anticorps EED, anticorps HEED, anticorps WAIT1, anticorps zgc:112509, anticorps Xeed-B, anticorps eed, anticorps psXEED, anticorps ENSMUSG00000039373, anticorps l(7)5Rn, anticorps l7Rn5, anticorps lusk, anticorps Xeed-A, anticorps embryonic ectoderm development, anticorps embryonic ectoderm development S homeolog, anticorps microRNA 6755, anticorps embryonic ectoderm development L homeolog, anticorps eed, anticorps EED, anticorps eed.S, anticorps MIR6755, anticorps Eed, anticorps eed.L

Sujet: Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extraembryonic tissues. May prevent transcriptional activation of facultative heterochromatin during differentiation. Required for development of secondary trophoblast giant cells during placental development. May regulate hippocampal synaptic plasticity in the developing brain.

UniProt: Q921E6