FBXW7 anticorps (N-Term)
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- Antigène Voir toutes FBXW7 Anticorps
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
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Épitope
- N-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FBXW7 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Purification
- Antigen affinity purified
- Immunogène
- This FBXW7 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 177-208 amino acids from the N-terminal region of human FBXW7.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product FBXW7 Anticorps primaire
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- Indications d'application
- Titration of the FBXW7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Aliquot the FBXW7 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Antigène
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
- Autre désignation
- FBXW7 (FBXW7 Produits)
- Synonymes
- anticorps cdc4, anticorps AGO, anticorps CDC4, anticorps FBW6, anticorps FBW7, anticorps FBX30, anticorps FBXO30, anticorps FBXW6, anticorps SEL-10, anticorps SEL10, anticorps hAgo, anticorps hCdc4, anticorps 1110001A17Rik, anticorps Cdc4, anticorps Fbw7, anticorps Fbwd6, anticorps Fbx30, anticorps Fbxo30, anticorps Fbxw6, anticorps F-box and WD repeat domain containing 7, anticorps F-box and WD-40 domain protein 7, anticorps Fbxw7, anticorps FBXW7, anticorps fbxw7
- Sujet
- Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. [UniProt]
- UniProt
- Q969H0
- Pathways
- Signalisation Notch, EGFR Signaling Pathway
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