FGFR4 anticorps (AA 24-55)

N° du produit ABIN3030958

Détail du produit anti-FGFR4 anticorps

Antigène: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Épitope: AA 24-55

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FGFR4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 24-55 from the human protein was used as the immunogen for this FGFR4 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the FGFR4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:200,Flow Cytometry: 1:10-1:50,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the FGFR4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur FGFR4

Antigène: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Autre désignation: FGFR4 (FGFR4 Produits)

Synonymes: anticorps FGFR4, anticorps XFGFR-4, anticorps XFGFR-4a, anticorps cd334, anticorps fgfr-4, anticorps jtk2, anticorps tkf, anticorps xfgfr4, anticorps CD334, anticorps JTK2, anticorps TKF, anticorps Fgfr-4, anticorps etID309818.21, anticorps wu:fc13h10, anticorps zgc:111935, anticorps fgfr-4c, anticorps fgfr4, anticorps fibroblast growth factor receptor 4, anticorps fibroblast growth factor receptor 4 S homeolog, anticorps FGFR4, anticorps fgfr4, anticorps Fgfr4, anticorps fgfr4.S

Sujet: FGFR4 is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR-4 signaling is down-regulated by receptor internalization and degradation, MMP14 promotes internalization and degradation of FGFR-4. Mutations that lead to constitutive kinase activation or impair normal FGFR-4 inactivation lead to aberrant signaling. [UniProt]

UniProt: P22455

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding