SYVN1 anticorps (AA 58-88)

N° du produit ABIN3029081

Détail du produit anti-SYVN1 anticorps

Antigène: SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

Épitope: AA 58-88

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SYVN1 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée (Details): Expected species reactivity: Mouse, Xenopus

Purification: Purified

Immunogène: A portion of amino acids 58-88 from the human protein was used as the immunogen for this HRD1 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the HRD1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the HRD1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur SYVN1

Antigène: SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

Autre désignation: HRD1 (SYVN1 Produits)

Synonymes: anticorps DER3, anticorps HRD1, anticorps hrd1, anticorps 1200010C09Rik, anticorps AW211966, anticorps C85322, anticorps D530017H19Rik, anticorps Hrd1, anticorps RGD1310488, anticorps syvn1, anticorps syvn1-a, anticorps syvn1-b, anticorps wu:fk91f10, anticorps zgc:55735, anticorps zgc:77108, anticorps synoviolin 1, anticorps synovial apoptosis inhibitor 1, synoviolin, anticorps synoviolin 1 S homeolog, anticorps SYVN1, anticorps syvn1, anticorps Syvn1, anticorps syvn1.S

Sujet: HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Synoviolin/Hrd1 (expressed in rheumatoid synovium) is reported to be a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects. HRD1 contains one ring-type zinc finger.

UniProt: Q86TM6

Pathways: ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling