IgD anticorps (AA 37-64)

N° du produit ABIN3031288

Détail du produit anti-IgD anticorps

Antigène: IgD

Épitope: AA 37-64

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IgD est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Purified

Immunogène: A portion of amino acids 37-64 from the human protein was used as the immunogen for this IGHD antibody.

Clone: 607CT8-4-4

Isotype: IgM

Information d'application

Indications d'application: Titration of the IGHD antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:100-1:250

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the IGHD antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur IgD

Antigène: IgD

Autre désignation: IGHD (IgD Produits)

Synonymes: anticorps IgD, anticorps Igh-5, anticorps immunoglobulin heavy constant delta, anticorps immunoglobulin delta heavy chain constant region, anticorps Ighd, anticorps Igd, anticorps IGHD

Classe de substances: Antibody

Sujet: IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.

UniProt: P01880