IGHM anticorps (AA 103-131)

N° du produit ABIN3031293

Détail du produit anti-IGHM anticorps

Antigène: IGHM (Immunoglobulin Heavy Constant mu (IGHM))

Épitope: AA 103-131

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IGHM est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB), ELISA

Purification: Purified

Immunogène: A portion of amino acids 103-131 from the human protein was used as the immunogen for this IGHM antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the IGHM antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the IGHM antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur IGHM

Antigène: IGHM (Immunoglobulin Heavy Constant mu (IGHM))

Autre désignation: IGHM (IGHM Produits)

Synonymes: anticorps AI326478, anticorps Igh-6, anticorps Igh-M, anticorps Igh6, anticorps Igm, anticorps muH, anticorps ighm1, anticorps wu:fj14a08, anticorps zgc:101769, anticorps AGM1, anticorps MU, anticorps VH, anticorps immunoglobulin heavy constant mu, anticorps Ighm, anticorps ighm, anticorps IGHM

Sujet: IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30 % of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts. [UniProt]

UniProt: P01871