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IGHM anticorps (AA 103-131)

IGHM Reactivité: Humain IHC, WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3031293
  • Antigène Tous les produits IGHM
    IGHM (Immunoglobulin Heavy Constant mu (IGHM))
    Épitope
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 103-131
    Reactivité
    • 25
    • 1
    • 1
    Humain
    Hôte
    • 14
    • 11
    Lapin
    Clonalité
    • 17
    • 8
    Polyclonal
    Conjugué
    • 21
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IGHM est non-conjugé
    Application
    • 12
    • 11
    • 10
    • 8
    • 7
    • 7
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB), ELISA
    Purification
    Purified
    Immunogène
    A portion of amino acids 103-131 from the human protein was used as the immunogen for this IGHM antibody.
    Isotype
    Ig Fraction
  • Indications d'application
    Titration of the IGHM antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS pH 7.4 with 0.09 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Aliquot the IGHM antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Antigène
    IGHM (Immunoglobulin Heavy Constant mu (IGHM))
    Autre désignation
    IGHM (IGHM Produits)
    Synonymes
    anticorps AI326478, anticorps Igh-6, anticorps Igh-M, anticorps Igh6, anticorps Igm, anticorps muH, anticorps ighm1, anticorps wu:fj14a08, anticorps zgc:101769, anticorps AGM1, anticorps MU, anticorps VH, anticorps immunoglobulin heavy constant mu, anticorps Ighm, anticorps ighm, anticorps IGHM
    Sujet
    IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30 % of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts. [UniProt]
    UniProt
    P01871
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