Integrin beta 7 anticorps (AA 737-765)

N° du produit ABIN3031382

Détail du produit anti-Integrin beta 7 anticorps

Antigène: Integrin beta 7 (ITGB7)

Épitope: AA 737-765

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Integrin beta 7 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 737-765 from the human protein was used as the immunogen for this Integrin beta 7 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the Integrin beta 7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Integrin beta 7 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur Integrin beta 7

Antigène: Integrin beta 7 (ITGB7)

Autre désignation: Integrin beta 7 (ITGB7 Produits)

Synonymes: anticorps Ly69, anticorps integrin beta 7, anticorps integrin subunit beta 7, anticorps integrin, beta 7, anticorps Itgb7, anticorps ITGB7

Sujet: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

UniProt: P26010

Pathways: Integrin Complex