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ISG15 anticorps (AA 31-61)

ISG15 Reactivité: Humain WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3031502
  • Antigène Voir toutes ISG15 Anticorps
    ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))
    Épitope
    • 10
    • 7
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 31-61
    Reactivité
    • 60
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 55
    • 6
    • 1
    Lapin
    Clonalité
    • 55
    • 7
    Polyclonal
    Conjugué
    • 36
    • 5
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ISG15 est non-conjugé
    Application
    • 48
    • 33
    • 29
    • 9
    • 7
    • 3
    • 3
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Purification
    Antigen affinity purified
    Immunogène
    A portion of amino acids 31-61 from the human protein was used as the immunogen for this ISG15 antibody.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product ISG15 Anticorps primaire
  • Indications d'application
    Titration of the ISG15 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:50-1:100,Western blot: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS pH 7.4 with 0.09 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Aliquot the ISG15 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Antigène
    ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))
    Autre désignation
    ISG15 (ISG15 Produits)
    Synonymes
    anticorps G1P2, anticorps IFI15, anticorps IP17, anticorps UCRP, anticorps hUCRP, anticorps ISG15, anticorps g1p2, anticorps si:rp71-1c23.2, anticorps G1p2, anticorps IGI15, anticorps Irfp, anticorps ISG17, anticorps ISG17/UCRP, anticorps ISG15 ubiquitin-like modifier, anticorps ISG15, anticorps isg15, anticorps Isg15
    Sujet
    ISG15 is secreted from monocytes in response to type I interferons and causes natural killer (NK)-cell proliferation and an augmentation of non-MCH (major histocompatibility complex)-restricted cytotoxicity. Synthesis is stimulated by IFN-alpha or IFN-beta or IFN-omega , but not IFN-gamma . ISG15 expression is also induced by overexpression of interferon regulatory factors that participate in transcriptional regulation of IFN genes, and by influenza B virus. ISG15 is secreted also by cell lines of monocyte, T-lymphocyte, B-lymphocyte, human fibroblasts, and epithelial origins. The induction of terminal differentiation in human melanoma cells is associated with alterations in ISG15 expression. Enhancement of NK cell proliferation, augmentation of non-major histocompatibility complex-restricted cytotoxicity, and induction of IFN-gamma from T cells identify ISG15 as a member of the cytokine cascade and suggest that it may be responsible for amplifying and directing some of the immunomodulatory effects of IFN-alpha or IFN-beta. ISG15 has has also been shown to function intracellularly as a ubiquitin homolog.
    UniProt
    P05161
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