JMJD4 anticorps (AA 1-30)

N° du produit ABIN3031514

Détail du produit anti-JMJD4 anticorps

Antigène: JMJD4 (Jumonji Domain Containing 4 (JMJD4))

Épitope: AA 1-30

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp JMJD4 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Purified

Immunogène: A portion of amino acids 1-30 from the human protein was used as the immunogen for this JMJD4 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the JMJD4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the JMJD4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur JMJD4

Antigène: JMJD4 (Jumonji Domain Containing 4 (JMJD4))

Autre désignation: JMJD4 (JMJD4 Produits)

Synonymes: anticorps JMJD4, anticorps 6430559I23, anticorps RGD1307186, anticorps jumonji domain containing 4, anticorps jumonji domain containing 4 L homeolog, anticorps JMJD4, anticorps jmjd4.L, anticorps Jmjd4

Sujet: Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

UniProt: Q9H9V9