MARK1 anticorps (AA 6-40)

N° du produit ABIN3031687

Détail du produit anti-MARK1 anticorps

Antigène: MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))

Épitope: AA 6-40

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MARK1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Purified

Immunogène: A portion of amino acids 6-40 from the human protein was used as the immunogen for this MARK1 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the MARK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the MARK1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur MARK1

Antigène: MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))

Autre désignation: MARK1 (MARK1 Produits)

Synonymes: anticorps MGC80341, anticorps MARK1, anticorps AW491150, anticorps B930025N23Rik, anticorps Emk3, anticorps Par-1c, anticorps mKIAA1477, anticorps mPar-1c, anticorps MARK, anticorps Par1c, anticorps MAP/microtubule affinity-regulating kinase 1 S homeolog, anticorps microtubule affinity regulating kinase 1, anticorps MAP/microtubule affinity-regulating kinase 1, anticorps MAP/microtubule affinity regulating kinase 1, anticorps mark1.S, anticorps MARK1, anticorps mark1, anticorps Mark1

Sujet: MARK is a family of kinases that is known for its involvement in establishing cell polarity and in phosphorylating tau protein during Alzheimer neurodegeneration. Expression of MARK causes the phosphorylation of MAPs at their KXGS motifs, thereby detaching MAPs from the microtubules and thus facilitating the transport of particles. This occurs without impairing the intrinsic activity of motors because the velocity during active movement remains unchanged. In primary retinal ganglion cells, transfection with tau leads to the inhibition of axonal transport of mitochondria, APP vesicles, and other cell components which leads to starvation of axons and vulnerability against stress. This transport inhibition can be rescued by phosphorylating tau with MARK

UniProt: Q9P0L2

Pathways: SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2