MAVS anticorps (AA 477-505)

N° du produit ABIN3031816

Détail du produit anti-MAVS anticorps

Antigène: MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))

Épitope: AA 477-505

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAVS est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 477-505 from the human protein was used as the immunogen for this MAVS antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the MAVS antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the MAVS antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur MAVS

Antigène: MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))

Autre désignation: MAVS (MAVS Produits)

Synonymes: anticorps CARDIF, anticorps IPS-1, anticorps IPS1, anticorps VISA, anticorps D430028G21Rik, anticorps Visa, anticorps cardif, anticorps wu:fj20d04, anticorps zgc:158392, anticorps mitochondrial antiviral signaling protein, anticorps MAVS, anticorps Mavs, anticorps mavs

Sujet: Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 or by the cytoplasmic RNA helicases MDA5 and RIGI. These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA and IKKB which activate NFKB, or TBK1 and IKKE (IKBKE, MIM 605048), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNB. For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF. For RIGI, the intermediary protein is mitochondria-bound IPS1.

UniProt: Q7Z434

Pathways: Activation of Innate immune Response, Inositol Metabolic Process, Hepatitis C