MIB1 anticorps (AA 13-42)
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- Antigène Voir toutes MIB1 Anticorps
- MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))
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Épitope
- AA 13-42
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MIB1 est non-conjugé
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Application
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Réactivité croisée (Details)
- Expected species reactivity: Mouse, Zebrafish, Xenopus
- Purification
- Purified
- Immunogène
- A portion of amino acids 13-42 from the human protein was used as the immunogen for this Mib1 antibody.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product MIB1 Anticorps primaire
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- Indications d'application
- Titration of the Mib1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:20-1:100,IHC (Paraffin): 1:50-1:100
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Aliquot the Mib1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Antigène
- MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))
- Autre désignation
- Mib1 (Mindbomb) (MIB1 Produits)
- Sujet
- MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
- UniProt
- Q86YT6
- Pathways
- SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2
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