MAP4K4 anticorps (AA 618-649)

N° du produit ABIN3031854

Détail du produit anti-MAP4K4 anticorps

Antigène: MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4))

Épitope: AA 618-649

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP4K4 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Purified

Immunogène: A portion of amino acids 618-649 from the human protein was used as the immunogen for this NIK antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the NIK antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the NIK antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur MAP4K4

Antigène: MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4))

Autre désignation: NIK (Nck-Interacting Kinase) (MAP4K4 Produits)

Synonymes: anticorps FLH21957, anticorps HGK, anticorps MEKKK4, anticorps NIK, anticorps 9430080K19Rik, anticorps AU043147, anticorps AU045934, anticorps AW046177, anticorps Nik, anticorps mitogen-activated protein kinase kinase kinase kinase 4, anticorps MAP4K4, anticorps Map4k4

Sujet: HGK/NIK, a member of the STE20 subfamily of Ser/Thr protein kinases, may play a role in the response to environmental stress and cytokines such as TNF-alpha. It appears to act upstream of the JUN N-terminal pathway. This protein is thought to interact with the SH3 domain of the adapter proteins Nck. HGK/NIK binds, via its CNH regulatory domain, to the N-terminal region of SPG3A. Expression appears to be ubiquitous, expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain, and isoform 4 is predominant in the liver, skeletal muscle and placenta.

UniProt: O95819