PTEN anticorps (AA 306-335)
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- Antigène Voir toutes PTEN Anticorps
- PTEN (Phosphatase and Tensin Homolog (PTEN))
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Épitope
- AA 306-335
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PTEN est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)
- Réactivité croisée (Details)
- Expected species reactivity: Mouse, Xenopus
- Purification
- Antigen affinity purified
- Immunogène
- A portion of amino acids 306-335 from the human protein was used as the immunogen for this PTEN antibody.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product PTEN Anticorps primaire
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- Indications d'application
- Titration of the PTEN antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50,IHC (Paraffin): 1:10-1:50
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- In 1X PBS pH 7.4 with 0.09 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Aliquot the PTEN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Antigène
- PTEN (Phosphatase and Tensin Homolog (PTEN))
- Autre désignation
- PTEN (PTEN Produits)
- Synonymes
- anticorps 10q23del, anticorps BZS, anticorps CWS1, anticorps DEC, anticorps GLM2, anticorps MHAM, anticorps MMAC1, anticorps PTEN1, anticorps TEP1, anticorps 2310035O07Rik, anticorps A130070J02Rik, anticorps AI463227, anticorps B430203M17Rik, anticorps Mmac, anticorps PTENP1, anticorps wu:fc52g04, anticorps zgc:73086, anticorps fa11a08, anticorps fb73f10, anticorps fc83f12, anticorps fd16b10, anticorps fk90e11, anticorps pten, anticorps si:bz1g13.4, anticorps wu:fa11a08, anticorps wu:fb73f10, anticorps wu:fc83f12, anticorps wu:fd16b10, anticorps wu:fk90e11, anticorps phosphatase and tensin homolog, anticorps phosphatase and tensin homolog L homeolog, anticorps phosphatase and tensin homolog A, anticorps phosphatase and tensin homolog B, anticorps PTEN, anticorps Pten, anticorps pten.L, anticorps ptena, anticorps ptenb
- Sujet
- This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
- UniProt
- P60484
- Pathways
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagy, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
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