PTEN anticorps (AA 306-335)

N° du produit ABIN3032200

Détail du produit anti-PTEN anticorps

Antigène: PTEN (Phosphatase and Tensin Homolog (PTEN))

Épitope: AA 306-335

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTEN est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Réactivité croisée (Details): Expected species reactivity: Mouse, Xenopus

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 306-335 from the human protein was used as the immunogen for this PTEN antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the PTEN antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50,IHC (Paraffin): 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the PTEN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur PTEN

Antigène: PTEN (Phosphatase and Tensin Homolog (PTEN))

Autre désignation: PTEN (PTEN Produits)

Sujet: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

UniProt: P60484

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagy, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling