RAC1 anticorps

N° du produit ABIN3032428

Détail du produit anti-RAC1 anticorps

Antigène: RAC1

Reactivité: Humain, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RAC1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Réactivité croisée (Details): Expected species reactivity: Bovine, Mouse

Purification: Purified

Immunogène: This RAC1 antibody was produced from a mouse immunized with a KLH conjugated synthetic peptide from the human protein.

Clone: 1301CT276-121-104

Isotype: IgG2b

Information d'application

Indications d'application: Titration of the RAC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Flow Cytometry: 1:100,IHC (Paraffin): 1:25,Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the RAC1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur RAC1

Antigène: RAC1

Abstract: RAC1 Produits

Synonymes: anticorps Rac-1, anticorps TC-25, anticorps p21-Rac1, anticorps AL023026, anticorps D5Ertd559e, anticorps RAC2, anticorps CRAC1A, anticorps rac1, anticorps wu:fd16e02, anticorps zgc:55823, anticorps zgc:55917, anticorps zgc:86934, anticorps 2248, anticorps CG2248, anticorps D-Rac, anticorps D-Rac 1, anticorps D-Rac1, anticorps DRac, anticorps DRac1, anticorps DRacA, anticorps Dm Rac1, anticorps DmRAC, anticorps DmRAC1, anticorps Dmel\CG2248, anticorps Dmrac1, anticorps Drac, anticorps Drac1, anticorps Drac1a, anticorps DracA, anticorps GTPase Rac1, anticorps P40792, anticorps RAC1, anticorps Rac, anticorps Rac GTPase, anticorps Rac3, anticorps RacA, anticorps dRac, anticorps dRac1, anticorps drac1, anticorps rac, anticorps Xrac, anticorps mig5, anticorps p21-rac1, anticorps tc-25, anticorps Rac family small GTPase 1, anticorps RAS-related C3 botulinum substrate 1, anticorps ras-related C3 botulinum toxin substrate 1, anticorps ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1), anticorps Rac family small GTPase 1a, anticorps CG2248 gene product from transcript CG2248-RB, anticorps Rac family small GTPase 1 L homeolog, anticorps ras homolog family member G, anticorps RAC1, anticorps Rac1, anticorps rac1a, anticorps rac1.L, anticorps RHOG

Sujet: Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2, this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.

UniProt: P63000

Pathways: Signalisation WNT, Regulation of Actin Filament Polymerization, Cell-Cell Junction Organization, Thromboxane A2 Receptor Signaling, VEGF Signaling