SMAD2 anticorps (AA 97-125)

N° du produit ABIN3032613

Détail du produit anti-SMAD2 anticorps

Antigène: SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

Épitope: AA 97-125

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMAD2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Réactivité croisée (Details): Expected species reactivity: Rat, Bovine, Pig, Chicken, Zebrafish, Drosophila

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 97-125 from the human protein was used as the immunogen for this SMAD2 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the SMAD2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Immunofluorescence: 1:100,Western blot: 1:1000,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the SMAD2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur SMAD2

Antigène: SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

Autre désignation: SMAD2 (SMAD2 Produits)

Synonymes: anticorps JV18, anticorps JV18-1, anticorps MADH2, anticorps MADR2, anticorps hMAD-2, anticorps hSMAD2, anticorps jv18, anticorps Xmad2, anticorps madh2, anticorps madr2, anticorps XSmad2, anticorps hmad-2, anticorps hsmad2, anticorps jv18-1, anticorps smad-2, anticorps fj43c06, anticorps wu:fj43c06, anticorps 7120426M23Rik, anticorps Madh2, anticorps Madr2, anticorps Smad-2, anticorps mMad2, anticorps MAD homolog 2, anticorps Mothers against DPP homolog 2, anticorps SMAD 2, anticorps Smad2, anticorps SMAD family member 2, anticorps SMAD family member 2-Z, anticorps SMAD family member 2 S homeolog, anticorps SMAD2, anticorps SMAD2Z, anticorps smad2, anticorps smad2.S, anticorps Smad2

Sujet: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. [UniProt]

UniProt: Q15796

Pathways: Cycle Cellulaire, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus