SREBF2 anticorps (AA 399-427)
-
- Antigène Voir toutes SREBF2 Anticorps
- SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))
-
Épitope
- AA 399-427
-
Reactivité
- Humain
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp SREBF2 est non-conjugé
-
Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Purification
- Antigen affinity purified
- Immunogène
- A portion of amino acids 399-427 from the human protein was used as the immunogen for this SREBP2 antibody.
- Isotype
- Ig Fraction
-
-
- Indications d'application
- Titration of the SREBP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Immunofluorescence: 1:10-1:50,Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Aliquot the SREBP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
-
- Antigène
- SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))
- Autre désignation
- SREBP2 (SREBF2 Produits)
- Synonymes
- anticorps SREBF2, anticorps srebp2, anticorps SREBP2, anticorps zgc:158371, anticorps AI608257, anticorps SREBP-2, anticorps SREBP2gc, anticorps bHLHd2, anticorps lop13, anticorps nuc, anticorps Srebf2_retired, anticorps sterol regulatory element binding transcription factor 2, anticorps sterol regulatory element binding factor 2, anticorps sterol regulatory element binding transcription factor 2 L homeolog, anticorps SREBF2, anticorps srebf2, anticorps Srebf2, anticorps srebf2.L
- Sujet
- SREBPs, including SREBP-1a, SREBP-1c, and SREBP-2, constitute a family of basic helix-loop-helix (bHLH) transcription factors that play a critical role in lipid homeostasis by regulating genes involved in cholesterol and fatty acid metabolism. Each SREBP consists of three domains, including an amino-terminal transcription factor domain of ~480 amino acids, a middle hydrophobic region of ~80 amino acids containing two hydrophobic transmembrane segments, and a carboxy-terminal regulatory domain of ~590 amino acids. SREBP-2 regulates cholesterol synthesis by activating the transcription of genes for HMG-CoA reductase and other enzymes of the cholesterol synthetic pathway. SREBP-2 is ubiquitously detected in various tissues. Under basal conditions SREBP is bound to ER membranes as a glycosylated precursor protein. Upon cholesterol depletion, the protein is cleaved to its active forms (about 50-68 kDa) and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol.
- UniProt
- Q12772
- Pathways
- Regulation of Lipid Metabolism by PPARalpha
-