Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

FLT4 anticorps

FLT4 Reactivité: Humain WB, ELISA, IHC, FACS Hôte: Souris Monoclonal 818CT12-1-1 unconjugated
N° du produit ABIN3030977
  • Antigène Voir toutes FLT4 Anticorps
    FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))
    Reactivité
    • 83
    • 50
    • 16
    • 11
    Humain
    Hôte
    • 72
    • 26
    • 9
    • 2
    Souris
    Clonalité
    • 73
    • 36
    Monoclonal
    Conjugué
    • 57
    • 11
    • 7
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FLT4 est non-conjugé
    Application
    • 56
    • 42
    • 37
    • 29
    • 15
    • 13
    • 13
    • 10
    • 9
    • 7
    • 5
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)
    Purification
    Purified
    Immunogène
    Purified His-tagged protein was used to produced this monoclonal VEGFR3 antibody.
    Clone
    818CT12-1-1
    Isotype
    IgG2a
    Top Product
    Discover our top product FLT4 Anticorps primaire
  • Indications d'application
    Titration of the VEGFR3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Flow Cytometry: 1:25,IHC (Paraffin): 1:25,Western blot: 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Aliquot the VEGFR3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Antigène
    FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))
    Autre désignation
    VEGFR3 (FLT4 Produits)
    Synonymes
    anticorps FLT41, anticorps LMPH1A, anticorps PCL, anticorps VEGFR3, anticorps AI323512, anticorps Chy, anticorps Flt-4, anticorps VEGFR-3, anticorps Vegfr3, anticorps cb1059, anticorps fms related tyrosine kinase 4, anticorps FMS-like tyrosine kinase 4, anticorps fms-related tyrosine kinase 4, anticorps FLT4, anticorps Flt4, anticorps flt4
    Sujet
    Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades, isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.
    UniProt
    P35916
    Pathways
    Signalisation RTK, Signaling Events mediated by VEGFR1 and VEGFR2, VEGF Signaling
Vous êtes ici:
Support technique