YAP1 anticorps (AA 420-446)
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- Antigène Voir toutes YAP1 Anticorps
- YAP1 (Yes-Associated Protein 1 (YAP1))
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Épitope
- AA 420-446
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp YAP1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Flow Cytometry (FACS)
- Purification
- Purified
- Immunogène
- A portion of amino acids 420-446 from human YAP1 was used as the immunogen for this YAP antibody.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product YAP1 Anticorps primaire
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- Indications d'application
- Titration of the YAP antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Flow Cytometry: 1:10-1:50
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Aliquot the YAP antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Antigène
- YAP1 (Yes-Associated Protein 1 (YAP1))
- Autre désignation
- YAP (YAP1 Produits)
- Synonymes
- anticorps YAP, anticorps YAP2, anticorps YAP65, anticorps YKI, anticorps xyap, anticorps yap, anticorps yap2, anticorps yap65, anticorps yki, anticorps AI325207, anticorps Yap, anticorps Yap65, anticorps Yki, anticorps Yorkie, anticorps cb194, anticorps sb:cb194, anticorps si:ch211-181p1.5, anticorps si:dkey-3b8.3, anticorps wu:fc18c04, anticorps zgc:158380, anticorps Yes associated protein 1, anticorps Yes associated protein 1 S homeolog, anticorps yes-associated protein 1, anticorps Yes-associated protein 1, anticorps YAP1, anticorps yap1.S, anticorps Yap1, anticorps yap1
- Sujet
- YAP is a transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. [UniProt]
- UniProt
- P46937
- Pathways
- Signalisation MAPK, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha
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