INHBC
Reactivité: Humain, Rat, Souris
WB, ELISA
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
The TGFbeta superfamily is composed of numerous growth and differentiation factors, including transforming growth factor beta (TGFbeta) 1, 2 and 3, growth/differentiation factor (GDF) 1 through 8, Mullerian inhibiting substance (MIS), bone morphogenic protein (BMP) 2 through 8, glial cell linederived neurotrophic factor (GDNF), inhibins (alpha, beta-A, beta-B and beta-C), Lefty and Nodal. Members of the TGFbeta superfamily are involved in embryonic development and adult tissue homeostasis. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins and activins are involved in regulating a number of functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth depending on their subunit composition. Activins oppose the funtions of inhibins. Inhibins are predominantly expressed in liver, uterus and ovary tissue, but also in benign prostatic hyperplasia. Inhibin A, a dimer of alpha and beta-A, and inhibin B, a dimer of alpha and beta-B, have been shown to inhibit the secretion of follicle stimulating hormone. Inhibin beta-C forms a homodimer and its expression is predominant in adult liver and in benign prostatic hyperplasia.Synonyms: Activin C, Activin beta-C chain