PLAU anticorps
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- Antigène Voir toutes PLAU Anticorps
- PLAU (Plasminogen Activator, Urokinase (PLAU))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PLAU est non-conjugé
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- This antibody detects endogenous levels of uPA protein. (region surrounding Leu239)
- Réactivité croisée (Details)
- Species reactivity (tested):Human.
- Purification
- Affinity chromatography
- Pureté
- > 95 % by SDS-PAGE
- Top Product
- Discover our top product PLAU Anticorps primaire
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- Indications d'application
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Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1,0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- PLAU (Plasminogen Activator, Urokinase (PLAU))
- Autre désignation
- uPA / PLAU (PLAU Produits)
- Synonymes
- anticorps PLAU, anticorps u-PA, anticorps ATF, anticorps BDPLT5, anticorps QPD, anticorps UPA, anticorps URK, anticorps uPA, anticorps UPAM, anticorps plasminogen activator, urokinase, anticorps urokinase-type plasminogen activator, anticorps PLAU, anticorps CpipJ_CPIJ002131, anticorps CpipJ_CPIJ006543, anticorps CpipJ_CPIJ013396, anticorps CpipJ_CPIJ013623, anticorps Plau
- Sujet
- UPA (urokinase-type plasminogen activator) and tPA (tissue plasminogen activator) are serine proteases that are members of the trypsin family, and they are essential to the intrinsic coagulation system. tPA is primarily involved in fibrinolysis, whereas uPA principally mediates cell migration and tissue remodeling processes. uPA and tPA are responsible for cleaving plasminogen, a large serum β-globulin that is deposited on the Fibrin strands within a thrombus. uPA and tPA preferentially target plasminogen at the Arg-Val bond to produce plasmin (also designated fibrinolysin), which is a trypsin-like enzyme that acts on Arg-Lys bonds in Fibrin and Fibrinogen and contributes to the systematic activation of the coagulation cascade. uPA and tPA each consist of two chains that are designated A and B. The A chain of uPA can be cleaved, resulting in low and high molecular mass forms. uPA and tPA are regulated by the serpin family members PAI-1 and PAI-2, which are serine proteinase inhibitors that complex with uPA, tPA and other targeted proteinases and then slowly disassociate to produce cleaved species that fold into stable inactive conformations.Synonyms: U-plasminogen activator, Urokinase, Urokinase-type plasminogen activator, Urokinase-type plasminogen activator chain B, Urokinase-type plasminogen activator long chain A, Urokinase-type plasminogen activator short chain A
- Poids moléculaire
- approx. 48 kDa
- ID gène
- 5328
- NCBI Accession
- NP_001138503
- UniProt
- P00749
- Pathways
- Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration
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