DIO3 anticorps
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- Antigène Voir toutes DIO3 Anticorps
- DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))
- Reactivité
- Humain, Rat, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp DIO3 est non-conjugé
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Application
- Western Blotting (WB)
- Specificité
- This antibody detects endogenous levels of DIO3 protein. (region surrounding Glu66)
- Réactivité croisée (Details)
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - Purification
- Affinity Chromatography using epitope-specific immunogen.
- Top Product
- Discover our top product DIO3 Anticorps primaire
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- Indications d'application
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Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Phosphate Buffered Saline (PBS), pH ~7.2, 0.05 % Sodium Azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))
- Autre désignation
- DIO3 (DIO3 Produits)
- Synonymes
- anticorps 5DIII, anticorps DIOIII, anticorps txdi3, anticorps dioiii, anticorps XL-15, anticorps itdi3, anticorps D3, anticorps TXDI3, anticorps iodothyronine deiodinase 3, anticorps deiodinase, iodothyronine, type 3, anticorps deiodinase, iodothyronine, type III, anticorps deiodinase, iodothyronine type III, anticorps deiodinase, iodothyronine, type 3 L homeolog, anticorps DIO3, anticorps dio3, anticorps Dio3, anticorps dio3.L
- Sujet
- DIO3 (deiodinase, iodothyronine, type III), also known as D3, 5DIII, TXDI3 or DIOIII, is a single-pass type II membrane protein that belongs to the iodothyronine deiodinase family of proteins. Members of the iodothyronine deiodinase family play an important role in thyroid hormone metabolism. Expressed in placenta and various fetal tissues, DIO3 localizes to the cell membrane and plays an important role regulating the activity of thyroid hormones during morphogenesis. More specifically, DIO3 functions as the major physiologic inactivator of thyroid hormones, catalyzing the inner-ring deiodination (the removal of iodine groups) of 3,5,3',5'-tetraiodothyronine (T4) and 3,5,3'-triiodothyronine (T3) to their inactive metabolites 3,3',5'-triiodothyronine (RT3 or reverse T3) and 3,3'-diiodothyronine (T2), respectively. Through its ability to inactivate thyroid hormones, DIO3 effects thermoregulation, gene expression and energy metabolism, as well as a number of other important reactions in cell maintenance and differentiation.Synonyms: 5DIII, DIOIII, ITDI3, TXDI3, Type 3 DI, Type III iodothyronine deiodinase, Type-III 5'-deiodinase
- Poids moléculaire
- approx. 30 kDa
- ID gène
- 1735
- NCBI Accession
- NP_001353
- UniProt
- P55073
- Pathways
- Hormone Activity
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