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IL12A anticorps
IL12A
Reactivité: Humain, Souris, Rat
IHC (p)
Hôte: Lapin
Polyclonal
unconjugated
Détail du produit anti-IL12A anticorps
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Antigène
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IL12A
(Interleukin 12 alpha (IL12A))
Reactivité
Toutes les réactivités sur IL12A Anticorps
Humain, Souris, Rat
Hôte
Toutes les hôtes sur IL12A Anticorps
Lapin
Clonalité
Toutes les clonalités sur IL12A Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers IL12A Anticorps
Cet anticorp IL12A est non-conjugé
Application
Tous les applications à travers IL12A Anticorps.
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificité
This antibody detects endogenous levels of IL-12A protein. (region surrounding Thr65)
Réactivité croisée (Details)
Species reactivity (expected):Mouse and RatSpecies reactivity (tested):Human.
Purification
Affinity chromatography
Pureté
> 95 % by SDS-PAGE
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Information d'application
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Indications d'application
Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Stockage
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Concentration
1,0 mg/mL
Buffer
PBS, pH 7.2, 0.05 % sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Détails sur IL12A
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Antigène
IL12A
(Interleukin 12 alpha (IL12A))
Autre désignation
Interleukin-12 alpha / IL12A (IL12A Produits )
Synonymes
anticorps CLMF, anticorps IL-12A, anticorps NFSK, anticorps NKSF1, anticorps P35, anticorps CLMF2, anticorps IL-12B, anticorps NKSF, anticorps NKSF2, anticorps p40, anticorps Il-12b, anticorps Il12p40, anticorps Il-12p40, anticorps Il12, anticorps IL-12p40, anticorps IL-12p35, anticorps Il-12a, anticorps Ll12a, anticorps p35, anticorps IL12p35, anticorps Il-12 p35, anticorps IL12p40, anticorps IL12, anticorps IL-12 p35, anticorps interleukin 12A, anticorps interleukin 12B, anticorps interleukin 12b, anticorps interleukin 12a, anticorps Interleukin 12 level, anticorps IL12A, anticorps IL12B, anticorps Il12b, anticorps Il12a, anticorps IL12, anticorps il12a
Sujet
IL-12 is secreted by macrophages and human B-lymphoblastoid cells in response to antigenic stimulation. This IL is responsible for the differentiation of naive CD4+ T cells into type 1 helper T cells that produce interferon-γ (IFN-γ). It also activates production of tumor necrosis factor α (TNFα) from T and natural killer (NK) cells, and it inhibits IL-4 mediated suppression of IFN-γ. IL-12 also has anti-angiogenic activity since the production of IFN-γ increases the production of inducible protein-10 (IP-10). IL-12 p40 represents a subunit of IL-12 that is induced by several pathogens. IL-12 p70 is a subunit of IL-12 that is controlled through both the p35 and p40 genes in a cell type-specific fashion.Synonyms: CLMF p35, Cytotoxic lymphocyte maturation factor 35 kDa subunit, IL-12 subunit p35, IL-12A, NK cell stimulatory factor chain 1, NKSF1
Poids moléculaire
approx. 25 kDa
ID gène
3592
NCBI Accession
NP_000873
UniProt
P29459
Pathways
Signalistation JAK/STAT , Regulation of Leukocyte Mediated Immunity , Positive Regulation of Immune Effector Process , Activated T Cell Proliferation
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