Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
anticorps CANDF7, anticorps ISGF-3, anticorps STAT91, anticorps 2010005J02Rik, anticorps AA408197, anticorps XStat1, anticorps STAT4, anticorps DD6G4-4, anticorps STAT, anticorps STAT1, anticorps dZ182H3.3, anticorps si:by134g18.2, anticorps si:by51f19.1, anticorps si:dz182h3.3, anticorps si:dz199m19.1, anticorps si:dz73o4.2, anticorps stat1, anticorps signal transducer and activator of transcription 1, anticorps signal transducer and activator of transcription 1 L homeolog, anticorps signal transducer and activator of transcription 1, 91kDa, anticorps signal transducer and activator of transcription 4, anticorps signal transducer and activator of transcription 1a, anticorps STAT1, anticorps Stat1, anticorps stat1.L, anticorps stat4, anticorps stat1a
Sujet
Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-alpha and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3beta appears to be activated by both while Stat3alpha is activated by EGF, but not by IL-6. Highest expresion of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.Synonyms: Signal transducer and activator of transcription 1-alpha/beta, Transcription factor ISGF-3 components p91/p84