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TNIP3 anticorps (C-Term)

TNIP3 Reactivité: Humain, Souris WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN499187
  • Antigène Voir toutes TNIP3 Anticorps
    TNIP3 (TNFAIP3 Interacting Protein 3 (TNIP3))
    Épitope
    • 15
    • 8
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    Humain, Souris
    Hôte
    • 33
    Lapin
    Clonalité
    • 33
    Polyclonal
    Conjugué
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TNIP3 est non-conjugé
    Application
    • 26
    • 13
    • 13
    • 11
    • 7
    • 6
    • 3
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody reactcs to ABIN3 near the carboxy terminus.
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    ABIN3 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human ABIN3.
    Isotype
    IgG
    Top Product
    Discover our top product TNIP3 Anticorps primaire
  • Indications d'application
    ELISA. Western Blot: ABIN3 antibody can be used for detection of ABIN3 at 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C.
  • Antigène
    TNIP3 (TNFAIP3 Interacting Protein 3 (TNIP3))
    Autre désignation
    TNIP3 (TNIP3 Produits)
    Synonymes
    anticorps ABIN-3, anticorps LIND, anticorps 9030611K07Rik, anticorps TNIP3, anticorps TNFAIP3 interacting protein 3, anticorps TNIP3, anticorps Tnip3
    Sujet
    The nuclear factor NF-kB plays key roles in development and immunity. ABIN3 (A20-binding inhibitor of NF-kB activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a novel negative feedback regulator of LPS-induced NF-kB activation. ABIN3 is a 39 kDa protein that negatively regulates NF-kB activation in response to TNF and LPS. ABIN3 is highly expressed in brain, thymus, lymph node, lung and fetal liver, with low expression in kidney, bone marrow. Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals and NF-kB inhibition is mediated by the ABIN-homology domain 2. ABIN3 has been found to be induced by Listeria infection and can be slightly downregulated by dexamethasone. Enhanced expression of ABIN3 in monocytes is associated with sepsis. Thus, ABIN3 is an IL-10-induced gene product capable of attenuating NF-kB in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions. At least four isoforms of ABIN3 are known to exist.Synonyms: A20-binding inhibitor of NF-kappa-B activation 3, ABIN-3, ABIN3, LIND, Listeria-induced gene protein, TNFAIP3-interacting protein 3
    ID gène
    79931
    NCBI Accession
    NP_079149
    UniProt
    Q96KP6
    Pathways
    Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin
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