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FYB anticorps (C-Term)

FYB Reactivité: Humain, Souris WB, IF, EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN499215
  • Antigène Voir toutes FYB Anticorps
    FYB (FYN-Binding Protein (FYB))
    Épitope
    • 15
    • 8
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 44
    • 7
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    Humain, Souris
    Hôte
    • 37
    • 6
    • 1
    Lapin
    Clonalité
    • 38
    • 6
    Polyclonal
    Conjugué
    • 25
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FYB est non-conjugé
    Application
    • 28
    • 19
    • 13
    • 13
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificité
    This antibody recognizes ADAP (C-term).
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    A 20 amino acid peptide from near the carboxy terminus of Human ADAP
    Isotype
    IgG
    Top Product
    Discover our top product FYB Anticorps primaire
  • Indications d'application
    ELISA. Western Blot: ADAP antibody can be used for detection of ADAP at 0.5 - 1 μg/mL. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % Sodium Azide as preservative
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    FYB (FYN-Binding Protein (FYB))
    Autre désignation
    FYN-Binding Protein (FYB Produits)
    Sujet
    The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappaB family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist.Synonyms: Adhesion and degranulation promoting adaptor protein, FYB-120/130, FYN-T-binding protein, SLAP-130, SLAP130, SLP-76-associated phosphoprotein, p120/p130
    ID gène
    2533
    NCBI Accession
    NP_955367
    UniProt
    O15117
    Pathways
    TCR Signaling, Protein targeting to Nucleus
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