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AICDA anticorps (C-Term)

AICDA Reactivité: Humain, Souris WB, IF, EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN499233
  • Antigène Voir toutes AICDA Anticorps
    AICDA (Activation-Induced Cytidine Deaminase (AICDA))
    Épitope
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 33
    • 15
    • 7
    • 2
    • 1
    Humain, Souris
    Hôte
    • 28
    • 2
    • 1
    • 1
    • 1
    Lapin
    Clonalité
    • 29
    • 4
    Polyclonal
    Conjugué
    • 23
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp AICDA est non-conjugé
    Application
    • 23
    • 17
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificité
    This antibody recognizes AID (C-term).
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    A Peptide corresponding to 14 amino acids near the carboxy-terminus of Human AID
    Isotype
    IgG
    Top Product
    Discover our top product AICDA Anticorps primaire
  • Indications d'application
    ELISA. Western Blot: AID antibody can be used for detection of AID at 1 - 2 μg/mL. Whole cell lysatefrom Ramos cells can be used as positive control. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % Sodium Azide as preservative
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Milillo, Molinario, Costanzi, Vischini, La Carpia, La Greca, Rigante, Gambaro, Gurrieri, Sangiorgi: "Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schönlein purpura." dans: Journal of nephrology, Vol. 31, Issue 5, pp. 731-741, (2018) (PubMed).

  • Antigène
    AICDA (Activation-Induced Cytidine Deaminase (AICDA))
    Autre désignation
    AICDA / AID (AICDA Produits)
    Synonymes
    anticorps AID, anticorps ARP2, anticorps CDA2, anticorps HIGM2, anticorps Aid, anticorps Arp2, anticorps aid, anticorps AICDA, anticorps arp2, anticorps cda2, anticorps higm2, anticorps xlaid, anticorps activation induced cytidine deaminase, anticorps activation-induced cytidine deaminase, anticorps activation-induced cytidine deaminase L homeolog, anticorps AICDA, anticorps Aicda, anticorps aicda, anticorps aicda.L
    Sujet
    Activation-induced cytidine deaminase (AID) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines (1). It is necessary for somatic hypermutation and class switch recombination in B cells (2), but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms (2,3). Although it is structurally and functionally similar to the APOBEC proteins (reviewed in 4), it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G (5).Synonyms: Activation-induced cytidine deaminase, Cytidine aminohydrolase
    ID gène
    57379
    NCBI Accession
    NP_065712
    UniProt
    Q9GZX7
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Production of Molecular Mediator of Immune Response
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