AIPL1 anticorps (Center)

N° du produit ABIN499251

Détail du produit anti-AIPL1 anticorps

Antigène: AIPL1 (Aryl Hydrocarbon Receptor Interacting Protein-Like 1 (AIPL1))

Épitope: Center

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AIPL1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to AIPL1.

Purification: Affinity chromatography purified via peptide column

Immunogène: Aipl1 antibody was raised against a 18 amino acid peptide near the center of the human Aipl1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: Aipl1 antibody can be used for detection of Aipl1 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur AIPL1

Antigène: AIPL1 (Aryl Hydrocarbon Receptor Interacting Protein-Like 1 (AIPL1))

Autre désignation: AIPL1 (AIPL1 Produits)

Synonymes: anticorps AIPL1, anticorps lca4, anticorps aipl2, anticorps AIPL2, anticorps LCA4, anticorps A930007I01Rik, anticorps aryl hydrocarbon receptor interacting protein like 1, anticorps aryl hydrocarbon receptor-interacting protein-like 1, anticorps AIPL1, anticorps aipl1, anticorps Aipl1

Sujet: Aipl1 was initially identified as a protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder thought to be caused by the abnormal development of photoreceptors. Aipl1 is a tetratricopeptide repeat protein that is highly homologous to ARA9, a protein involved in the HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor. Aipl1 has also been found to function as part of a chaperone heterocomplex, interacting with Hsp90 and Hsp70. Aipl1 also associates with the cell cycle regulator NUB1. It is thought that Aipl1 cooperates with Hsp70 but not Hsp90 to suppress the formation of NUB1 inclusions, and these interactions are necessary in the normal photoreceptor maturation, as mutations that lead to LCA also compromise the interactions with the Hsp chaperones. At least three isoforms of Aipl1 are known to exist.Synonyms: Aryl-hydrocarbon-interacting protein-like 1

ID gène: 23746

NCBI Accession: NP_055151

UniProt: Q9NZN9