AVEN anticorps (N-Term)

N° du produit ABIN499369

Détail du produit anti-AVEN anticorps

Antigène: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AVEN est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to AVEN.

Purification: Affinity chromatography purified via peptide column

Immunogène: Aven antibody was raised against a 18 amino acid peptide from near the amino terminus of human Aven.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: Aven antibody can be used for detection of Aven at 0.5 to 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur AVEN

Antigène: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Autre désignation: AVEN (AVEN Produits)

Synonymes: anticorps AVEN, anticorps pdcd12, anticorps aven, anticorps wu:fc08c09, anticorps si:ch211-150c22.4, anticorps PDCD12, anticorps 1700013A01Rik, anticorps 1700056A21Rik, anticorps mAven-L, anticorps mAven-S, anticorps apoptosis and caspase activation inhibitor, anticorps apoptosis, caspase activation inhibitor L homeolog, anticorps apoptosis, caspase activation inhibitor, anticorps Aven, anticorps AVEN, anticorps aven.L, anticorps aven

Sujet: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients. Despite its predicted molecular weight, Aven often migrates at 55 kDa in SDS-PAGE.Synonyms: Cell death regulator Aven, PDCD12, Programmed cell death 12

ID gène: 57099

NCBI Accession: NP_065104

UniProt: Q9NQS1