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BORA anticorps (N-Term)

BORA Reactivité: Humain, Souris, Rat WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN499491
  • Antigène Voir toutes BORA Anticorps
    BORA (Protein Aurora Borealis (BORA))
    Épitope
    • 15
    • 7
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 41
    • 2
    • 1
    Lapin
    Clonalité
    • 44
    Polyclonal
    Conjugué
    • 12
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp BORA est non-conjugé
    Application
    • 23
    • 13
    • 13
    • 12
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody reacts to BORA.
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    Bora antibody was raised against a 15 amino acid peptide from near the amino terminus of human Bora.
    Isotype
    IgG
    Top Product
    Discover our top product BORA Anticorps primaire
  • Indications d'application
    ELISA. Western Blot: Bora antibody can be used for detection of Bora at 1-2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C.
  • Antigène
    BORA (Protein Aurora Borealis (BORA))
    Autre désignation
    Protein Aurora Borealis (BORA Produits)
    Synonymes
    anticorps CG6897, anticorps Dmel\\CG6897, anticorps zgc:101616, anticorps C13orf34, anticorps 6720463M24Rik, anticorps AI317232, anticorps RGD1309522, anticorps c13orf34, anticorps C12H13orf34, anticorps aurora borealis, anticorps bora, aurora kinase A activator, anticorps protein aurora borealis, anticorps bora, aurora kinase A activator S homeolog, anticorps bora, anticorps Tsp_06066, anticorps Bora, anticorps BORA, anticorps bora.S
    Sujet
    Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), which is a centrosome-associated serine/threonine kinase that regulates centrosome maturation, bipolar spindle assembly and chromosome segregation during mitosis. Bora is localized to the nucleus until mitosis is initiated, then translocates to the cytoplasm in a Cdc2 dependent manner. Activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate ARK-1. PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1. Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry. Bora mutants result in multipolar spindles in mitosis identical to those observed when ARK-1 function is blocked. Thus, the ARK1-Bora-PLK1 regulatory circuit in mammalian cells elucidates a key mechanism in cell cycle regulation. At least three isoforms of Bora are known to exist.Synonyms: BORA, C13orf34, FLJ22624, HsBora
    ID gène
    79866
    UniProt
    Q6PGQ7
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