Carabin anticorps (C-Term)

N° du produit ABIN499529

Détail du produit anti-Carabin anticorps

Antigène: Carabin (TBC1D10C) (TBC1 Domain Family, Member 10C (TBC1D10C))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Carabin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to Carabin.

Purification: Affinity chromatography purified via peptide column

Immunogène: Carabin antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human Carabin.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: Carabin antibody can be used for detection of Carabin at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur Carabin

Antigène: Carabin (TBC1D10C) (TBC1 Domain Family, Member 10C (TBC1D10C))

Autre désignation: Carabin (TBC1D10C Produits)

Synonymes: anticorps CARABIN, anticorps EPI64C, anticorps 1810062O14Rik, anticorps AI428527, anticorps RGD1311490, anticorps TBC1 domain family member 10C, anticorps TBC1 domain family, member 10c, anticorps TBC1 domain family, member 10C, anticorps TBC1D10C, anticorps Tbc1d10c

Sujet: Antigen binding by the T-cell receptor (TCR) is one of the critical first steps in the immune response, triggering a cascade of signaling pathways that ultimately lead to T-cell activation. Screening a yeast two-hybrid screen of a human T-cell cDNA library with calcineurin, a protein phosphatase involved in multiple signaling pathways including T-cell activation, resulted in the identification of Carabin, a member of the TBC1 domain family of proteins, as a calcineurin-binding protein. Unlike other members of the TBC1 domain protein family which are thought to have a role in regulating cell growth and differentiation, further experiments demonstrated that Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway as well as an inhibitor of the Ras signaling pathway, suggesting that Carabin may also mediate crosstalk between calcineurin and Ras. Carabin antibody does not recognize TBC1D10A or TBC1D10B. Carabin is known to exist in multiple isoforms.Synonyms: TBC1 domain family member 10C, TBC1D10C

ID gène: 374403

NCBI Accession: NP_940919

UniProt: Q8IV04