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CCDC98 anticorps (N-Term)

FAM175A Reactivité: Humain, Souris WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN499595
  • Antigène Voir toutes CCDC98 (FAM175A) Anticorps
    CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))
    Épitope
    • 15
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    N-Term
    Reactivité
    • 24
    • 18
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 36
    • 4
    Lapin
    Clonalité
    • 36
    • 4
    Polyclonal
    Conjugué
    • 17
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CCDC98 est non-conjugé
    Application
    • 31
    • 13
    • 13
    • 13
    • 11
    • 8
    • 6
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody reacts to CCDC98.
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    CCDC98 antibody was raised against a 15 amino acid peptide from near the amino terminus of human CCDC98.
    Isotype
    IgG
    Top Product
    Discover our top product FAM175A Anticorps primaire
  • Indications d'application
    ELISA. Western Blot: CCDC98 antibody can be used for detection of CCDC98 at 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C.
  • Antigène
    CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))
    Autre désignation
    CCDC98 (FAM175A Produits)
    Synonymes
    anticorps CCDC98, anticorps abra1, anticorps ccdc98, anticorps fam175a, anticorps ABRA1, anticorps 3830405G04Rik, anticorps 5630400M01Rik, anticorps AI506069, anticorps AL024423, anticorps AV118690, anticorps Ccdc98, anticorps RGD1305287, anticorps zgc:103522, anticorps abraxas 1, BRCA1 A complex subunit, anticorps Coiled-coil domain-containing protein 98, anticorps BRCA1 A complex subunit, anticorps family with sequence similarity 175 member A, anticorps abraxas 2a, BRISC complex subunit, anticorps abraxas 1, BRCA1 A complex subunit S homeolog, anticorps ABRAXAS1, anticorps abraxas1, anticorps Abraxas1, anticorps FAM175A, anticorps abraxas2a, anticorps abraxas1.S
    Sujet
    CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.Synonyms: ABRA1, Abraxas, BRCA1-A complex subunit Abraxas, Coiled-coil domain-containing protein 98, Protein FAM175A
    ID gène
    84142
    NCBI Accession
    NP_620775
    UniProt
    Q6UWZ7
    Pathways
    Réparation de l'ADN, Positive Regulation of Response to DNA Damage Stimulus
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