CDCA8 anticorps (N-Term)

N° du produit ABIN499603

Détail du produit anti-CDCA8 anticorps

Antigène: CDCA8 (Cell Division Cycle Associated 8 (CDCA8))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDCA8 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to CDCA8.

Purification: Affinity chromatography purified via peptide column

Immunogène: CDCA8 antibody was raised against a 19 amino acid peptide near the amino terminus of the human CDCA8.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: CDCA8 antibody can be used for detection of CDCA8 at 1 μg/mL. Immunofluorescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur CDCA8

Antigène: CDCA8 (Cell Division Cycle Associated 8 (CDCA8))

Autre désignation: CDCA8 / Borealin (CDCA8 Produits)

Synonymes: anticorps BOR, anticorps BOREALIN, anticorps DasraB, anticorps MESRGP, anticorps Bor, anticorps Borr, anticorps CG4454, anticorps Dmel\\CG4454, anticorps dBor, anticorps borea, anticorps Dasra-B, anticorps GgDasraB, anticorps 4831429J16Rik, anticorps AU044747, anticorps Borealin, anticorps D4Ertd421e, anticorps bor, anticorps dasrab, anticorps borealin, anticorps cdca8l, anticorps sb:cb373, anticorps zgc:101607, anticorps cell division cycle associated 8, anticorps borealin-related, anticorps Borealin, anticorps cell division cycle associated 8 L homeolog, anticorps CDCA8, anticorps borr, anticorps borea, anticorps Cdca8, anticorps cdca8.L, anticorps cdca8

Sujet: CDCA8 is a component of a chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The chromosomal passenger complex, which includes Survivin, CDCA8, INCENP and Aurora-B, is known to play crucial roles during mitosis and cell division. It was found that CDCA8 interacting with Aurora-B, INCENP and Survivin, increases during G2/M phase and then reduces after exit from M phase. CDCA8 is cell cycle regulated, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. In Drosophila cells, inactivation of CDCA8 results in polyploidy, delayed mitosis and abnormal tissue development, indicating its critical role for cell proliferation. Recent studies show that CDCA8 is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53. Its aberrant expression is linked to a poor prognosis for gastric cancer.Synonyms: Cell division cycle-associated protein 8, Dasra-B, PESCRG3, Pluripotent embryonic stem cell-related gene 3 protein, hDasra-B

ID gène: 55143

NCBI Accession: NP_060571

UniProt: Q53HL2

Pathways: Cycle Cellulaire, M Phase