DARC anticorps (N-Term)

N° du produit ABIN499712

Détail du produit anti-DARC anticorps

Antigène: DARC (Duffy Blood Group, Chemokine Receptor (DARC))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DARC est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to DARC.

Purification: Affinity chromatography purified via peptide column

Immunogène: DARC antibody was raised against a 18 amino acid peptide from near the amino terminus of human DARC.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur DARC

Antigène: DARC (Duffy Blood Group, Chemokine Receptor (DARC))

Autre désignation: CD234 / DARC (DARC Produits)

Synonymes: anticorps DARC, anticorps FY, anticorps ACKR1, anticorps CCBP1, anticorps CD234, anticorps Dfy, anticorps GPD, anticorps GpFy, anticorps WBCQ1, anticorps AA162249, anticorps Ackr1, anticorps ESTM35, anticorps Duffy blood group, chemokine receptor, anticorps atypical chemokine receptor 1 (Duffy blood group), anticorps atypical chemokine receptor 1, anticorps DARC, anticorps ACKR1, anticorps Ackr1

Sujet: DARC, also known as the Duffy antigen/chemokine receptor, is a seven-transmembrane protein homologous to the classical chemokine G-protein coupled receptors (GPCRs) with the exception of the motif required for G protein coupling. DARC can bind with high affinity several chemokines without transducing any signal, suggesting it may modulate the signals normally induced by these chemokines. Recently, DARC was found to interact with KAI1, a four transmembrane protein recently identified as a tumor metastasis suppressor protein. It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor cells that have lost KAI1 expression can proliferate and potentially give rise to metastases. At least three isoforms of DARC are known to exist.Synonyms: Duffy antigen/chemokine receptor, FY, Fy glycoprotein, GPD, Glycoprotein D, GpFy, Plasmodium vivax receptor

ID gène: 2532

UniProt: Q16570