EBI3 anticorps (Center)
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- Antigène Voir toutes EBI3 (IL-27b) Anticorps
- EBI3 (IL-27b) (Interleukin-27 subunit beta (IL-27b))
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Épitope
- Center
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp EBI3 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- Specificité
- This antibody reacts to EBI3.
- Purification
- Affinity chromatography purified via peptide column
- Immunogène
- EBI3 antibody was raised against a 16 amino acid peptide from near the center of human EBI3.
- Isotype
- IgG
- Top Product
- Discover our top product IL-27b Anticorps primaire
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- Indications d'application
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ELISA. Western Blot: 2 - 4 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- PBS containing 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C.
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- Antigène
- EBI3 (IL-27b) (Interleukin-27 subunit beta (IL-27b))
- Autre désignation
- EBI3 / IL27B (IL-27b Produits)
- Synonymes
- anticorps IL-27B, anticorps IL27B, anticorps EBI3, anticorps il-27rb, anticorps si:dkey-97a13.4, anticorps EBI-3, anticorps IL-27, anticorps Epstein-Barr virus induced 3, anticorps Epstein-Barr virus induced gene 3, anticorps EBI3, anticorps ebi3, anticorps Ebi3
- Classe de substances
- Viral Protein
- Sujet
- EBI3 is a subunit in two distinct heterodimeric cytokines: interleukin-27 (IL-27) and IL-35 (1-3). Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 (also known as TCCR) and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-g, and T-bet. IL-35 is composed of EBI3 and the p35 subunit of IL-12 and has been reported to have therapeutic effects against collagen-induced arthritis by expanding the population of regulatory T cells and suppressing Th17 cells. At least two isoform of EBI3 are known to exist.Synonyms: EBV-induced gene 3 protein, Epstein-Barr virus-induced gene 3 protein, IL-27 subunit beta, IL-27B, Interleukin-27 subunit beta
- ID gène
- 10148
- NCBI Accession
- NP_005746
- UniProt
- Q14213
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