TMC8 anticorps (Center)

N° du produit ABIN499810

Détail du produit anti-TMC8 anticorps

Antigène: TMC8 (Transmembrane Channel-Like 8 (TMC8))

Épitope: Center

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TMC8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to EVER2.

Purification: Affinity chromatography purified via peptide column

Immunogène: EVER2 antibody was raised against a 14 amino acid peptide from near the center of human EVER2.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blt: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur TMC8

Antigène: TMC8 (Transmembrane Channel-Like 8 (TMC8))

Autre désignation: TMC8 (TMC8 Produits)

Synonymes: anticorps EV2, anticorps EVER2, anticorps EVIN2, anticorps Ever2, anticorps mFLJ00400, anticorps transmembrane channel like 8, anticorps transmembrane channel-like 8, anticorps transmembrane channel-like gene family 8, anticorps TMC8, anticorps Tmc8

Sujet: Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the majority of EV cases. These two proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2 accumulated higher levels of zinc in the nucleolus and nucleus compare to those cells with and intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc. At least three isoforms of EVER2 are known to exist, this antibody will only recognize the larger isoform. EVER2 has no cross-reactivity to EVER1.Synonyms: EVER2, EVIN2, Epidermodysplasia verruciformis protein 2, Transmembrane channel-like protein 8

ID gène: 147138

UniProt: Q8IU68