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TMC8 anticorps (Center)

TMC8 Reactivité: Humain, Souris, Rat WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN499810
  • Antigène Voir toutes TMC8 Anticorps
    TMC8 (Transmembrane Channel-Like 8 (TMC8))
    Épitope
    • 15
    • 7
    • 7
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 42
    Lapin
    Clonalité
    • 42
    Polyclonal
    Conjugué
    • 11
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TMC8 est non-conjugé
    Application
    • 34
    • 20
    • 13
    • 13
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody reacts to EVER2.
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    EVER2 antibody was raised against a 14 amino acid peptide from near the center of human EVER2.
    Isotype
    IgG
    Top Product
    Discover our top product TMC8 Anticorps primaire
  • Indications d'application
    ELISA. Western Blt: 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C.
  • Antigène
    TMC8 (Transmembrane Channel-Like 8 (TMC8))
    Autre désignation
    TMC8 (TMC8 Produits)
    Synonymes
    anticorps EV2, anticorps EVER2, anticorps EVIN2, anticorps Ever2, anticorps mFLJ00400, anticorps transmembrane channel like 8, anticorps transmembrane channel-like 8, anticorps transmembrane channel-like gene family 8, anticorps TMC8, anticorps Tmc8
    Sujet
    Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the majority of EV cases. These two proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2 accumulated higher levels of zinc in the nucleolus and nucleus compare to those cells with and intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc. At least three isoforms of EVER2 are known to exist, this antibody will only recognize the larger isoform. EVER2 has no cross-reactivity to EVER1.Synonyms: EVER2, EVIN2, Epidermodysplasia verruciformis protein 2, Transmembrane channel-like protein 8
    ID gène
    147138
    UniProt
    Q8IU68
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