FAM59A anticorps (C-Term)

N° du produit ABIN499824

Détail du produit anti-FAM59A anticorps

Antigène: FAM59A (Family with Sequence Similarity 59, Member A (FAM59A))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAM59A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogène: FAM59A antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human FAM59A.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Détails sur FAM59A

Antigène: FAM59A (Family with Sequence Similarity 59, Member A (FAM59A))

Autre désignation: FAM59A (FAM59A Produits)

Synonymes: anticorps C18orf11, anticorps FAM59A, anticorps Gm944, anticorps C86169, anticorps Fam59a, anticorps mKIAA4238, anticorps fam59a, anticorps zgc:55634, anticorps GRB2 associated regulator of MAPK1 subtype 1, anticorps GRB2 associated, regulator of MAPK1, anticorps GAREM1, anticorps Garem1, anticorps garem

Sujet: FAM59A, also known as GAREM, was initially identified through a mass spectroscoptic method that measures different phosphotyrosine states of proteins in response to different cell stimuli. FAM59A is a downstream molecule in the EGF signaling pathway that is tyrosine-phosphorylated, and this phosphorylation is needed for the binding of Grb2, an adaptor protein crucial to the transduction of growth signals from the plasma membrane to the nucleus. ERK activation in response to EGF stimulation is regulated by FAM59A in COS-7 and HeLa cells, and the overexpression of FAM59A stimulated cell proliferation and colony formation in soft agar, suggesting that FAM59A might be a critical protein with roles in ligand-mediated signaling pathway of the EGF receptor and the tumorigenesis of cells.Synonyms: C18orf11

ID gène: 64762

UniProt: Q9H706

Pathways: EGFR Signaling Pathway