FRMPD4 anticorps (Center)

N° du produit ABIN499861

Détail du produit anti-FRMPD4 anticorps

Antigène: FRMPD4 (FERM and PDZ Domain Containing 4 (FRMPD4))

Épitope: Center

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FRMPD4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogène: FRMPD4 antibody was raised against an 18 amino acid peptide from near the center of human FRMPD4.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Détails sur FRMPD4

Antigène: FRMPD4 (FERM and PDZ Domain Containing 4 (FRMPD4))

Autre désignation: FRMPD4 (FRMPD4 Produits)

Synonymes: anticorps RGD1566031, anticorps PDZD10, anticorps PDZK10, anticorps Gm196, anticorps PKAP1, anticorps Pdzd10, anticorps Pdzk10, anticorps Preso1, anticorps FERM and PDZ domain containing 4, anticorps Frmpd4, anticorps FRMPD4, anticorps frmpd4

Sujet: The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD4, also known as Preso, also contains another protein interaction domain termed WW (domain with two conserved Trp residues) at its amino terminus. It was identified through a yeast two-hybrid screen using the PDZ domain of PSD-95 as bait and is highly expressed in multiple regions of the brain and is enriched in the postsynaptic density (PSD) fractions. Overexpression of FRMPD4 in cultured hippocampal neurons significantly increased the linear density of dendritic spines without changing their length and width, conversely, knockdown experiments using RNAi caused a decrease in spine density, indicating FRMPD4 positively regulates dendritic spine density but not morphology. The decreased level of FRMPD4 also resulted in reduced levels of excitatory synaptic transmission, suggesting that FRMPD4 is required for maintenance of excitatory synaptic transmission.Synonyms: FERM and PDZ domain-containing protein 4, KIAA0316, PDZ domain-containing protein 10, PDZD10, PDZK10, PSD-95-interacting regulator of spine morphogenesis, Preso

ID gène: 9758

NCBI Accession: NP_055543

UniProt: Q14CM0