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GPR3 anticorps (C-Term)

GPR3 Reactivité: Humain, Souris, Rat WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN499914
  • Antigène Voir toutes GPR3 Anticorps
    GPR3 (G Protein-Coupled Receptor 3 (GPR3))
    Épitope
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 30
    • 16
    • 14
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 28
    • 4
    • 1
    Lapin
    Clonalité
    • 31
    • 2
    Polyclonal
    Conjugué
    • 21
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GPR3 est non-conjugé
    Application
    • 16
    • 13
    • 10
    • 7
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody reacts to GPR3.
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    GPR3 antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human GPR3.
    Isotype
    IgG
    Top Product
    Discover our top product GPR3 Anticorps primaire
  • Indications d'application
    ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C.
  • Antigène
    GPR3 (G Protein-Coupled Receptor 3 (GPR3))
    Autre désignation
    GPR3 / ACCA (GPR3 Produits)
    Synonymes
    anticorps GPR3, anticorps ACCA, anticorps Gpcr3, anticorps Gpcr20, anticorps Gpcr21, anticorps G protein-coupled receptor 3, anticorps G-protein coupled receptor 3, anticorps GPR3, anticorps Gpr3
    Sujet
    GPR3, also known as ACCA, is a G-protein coupled receptor that constitutively activates adenylate cyclase and is highly expressed in the central nervous system. Overexpression of GPR3 stimulates the production of amyloid-b peptide (Ab), the deposition of which is one of the pathological hallmarks of Alzheimer 's disease (AD), while the ablation of GPR3 prevented the accumulation of Ab in vitro and in an AD mouse model. This is of particular interest because of the proximity of a reported candidate Alzheimer 's disease (AD) locus, suggesting that GPR3 may be a potential therapeutic target for the treatment of AD. GPR3 has also been shown to block the proliferation of cerebellar granule cell precursors (GCP) during postnatal development by inhibiting the Shh-induced proliferation of GCP, indicating that GPR3 activation may represent one of the signals that triggers the postnatal cell cycle exit and terminal differentiation of GPCs.Synonyms: ACCA orphan receptor, G-protein coupled receptor 3
    ID gène
    2827
    UniProt
    P46089
    Pathways
    cAMP Metabolic Process
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