GP6 anticorps (C-Term)

N° du produit ABIN499916

Détail du produit anti-GP6 anticorps

Antigène: GP6 (Glycoprotein VI (Platelet) (GP6))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GP6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to GPVI.

Purification: Affinity chromatography purified via peptide column

Immunogène: GPVI antibody was raised against a 15 amino acid peptide near the carboxy terminus of the human GPVI.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur GP6

Antigène: GP6 (Glycoprotein VI (Platelet) (GP6))

Autre désignation: Platelet Glycoprotein VI (GP6 Produits)

Synonymes: anticorps BDPLT11, anticorps GPIV, anticorps GPVI, anticorps 9830166G18Rik, anticorps Gm469, anticorps Gpvi, anticorps GP6, anticorps glycoprotein VI platelet, anticorps glycoprotein 6 (platelet), anticorps glycoprotein VI, anticorps platelet glycoprotein VI, anticorps GP6, anticorps Gp6, anticorps LOC103346235

Sujet: Glycoprotein VI (GP6) is a 58kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. It is uniquely expressed by cells of the megakaryocytic/platelet lineage, and is a member of the immunoglobulin gene superfamily, closely related to Fc receptor gamma chain (FcR) and natural killer receptors. Glycoprotein VI plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. GPVI deficiency can result in bleeding disorders. Further study should reveal the extent of GPVI involvement in thrombotic disease and allow the development of alternative anti-thrombotic compounds.Synonyms: GP6, GPVI, Glycoprotein 6

ID gène: 51206

NCBI Accession: NP_057447

UniProt: Q9HCN6